CCB Colloquium presentation by Dr. Christian Atsriku, Celgene.
Host: Gene Hall
Talk Title: "Drug Metabolite Profiling and Identification using High Resolution Mass Spectrometry and Associated Technologies"
Abstract: Metabolite identification plays a critical role in drug discovery and development. In recognition of the potential pharmacological and toxicological implications of drug metabolites, regulatory agencies have issued guidances that necessitate human metabolite safety testing in preclinical species. Recently, the development of high-resolution mass spectrometry with high mass accuracy, has reshaped the landscape of metabolite identification by facilitating the process of detection of drug-related analytes and unpredicted biotransformtions in complex biological matrices. This has led to the emergence of a wide range of experimental strategies and post-acquisition data processing and mining techniques which are indispensable for rapid metabolite identification. This talk will explore current applications of HR-MS and post-acquisition techniques for metabolite profiling and identification.