CCB Colloquium presentation by Dr. Muhammad N. Yousaf, University of North Carolina at Chapel Hill.
Host: Dr. KiBum Lee
Talk Title: "Integrating surfaces with organic chemistry applied to dynamic studies of cell behavior and the development of biomaterials for cell tissue engineering"
Abstract: This seminar will describe two recent projects. 1. Interfacing surface chemistry with cell biology to generate new proteomic microarrays and dynamic surfaces to study cell behavior and stem cell differentiation. 2. The development of new biodegradable biomaterials via a general synthetic chemoselective redox responsive ligation (click) and release strategy applied to cell surface engineering to control dynamic 3-D cell tissue interactions.
1. An Electroactive Catalytic Dynamic Substrate that Immobilizes and Releases Patterned Ligands, Proteins and Cells. E.W.L. Chan, S. Park, M.N. Yousaf Angew. Chem. Int. Ed. 2008, 47, 6267-6271.
2. Asymmetric Peptide Nanoarray Surfaces for Studies of Single Cell Polarization. D.K. Hoover, E.W.L. Chan and M.N. Yousaf. J. Am. Chem. Soc. 2008, 130, 3280-3281.
3. Rapid In-Situ Generation of Two Patterned Chemoselective Orthogonal Surface Chemistries from a Single Hydroxy-Terminated Surface Using Controlled Microfluidic Oxidation. A. Pulsipher, N.P. Westcott, W. Luo, M.N. Yousaf. J. Am. Chem. Soc. 2009. 131, 7626-7632.
4. Microfluidic Permeation Printing of Self-Assembled Monolayer Gradients on Surfaces for Chemoselective Ligand Immobilization Applied to Cell Adhesion and Polarization B.M. Lamb and M.N. Yousaf. Langmuir. 2010, 26, 12817-12823.
5. A Renewable, Chemoselective, and Quantitative Ligand Density Spot Microarray for the Study of High-Throughput Biospecific Interactions. A. Pulsipher and M.N. Yousaf. Chem. Comm. 2011. (Special Issue on Emerging Investigators) 47, 523-525
Dr. Yousaf is currently a Professor in the Department of Chemistry and associated with the Carolina Center for Genome Sciences at the University of North Carolina at Chapel Hill. His research interests are in interfacing organic, bioanalytical, bioengineering and cell biology research to study fundamental cell behavior and to develop new biomaterials and tools for regenerative medicine applications. As a PI, he has published more than 50 original papers, given over 50 seminars at universities and conferences and has been elected to serve on 3 journal advisory and editorial boards. Dr. Yousaf has received several national awards including, a Damon Runyon Fellowship, Burroughs Wellcome Interface Career Award and an NSF CAREER award and is a key member of the Carolina Center for Cancer Nanotechnology and Energy Frontiers Research Center. Dr. Yousaf's highschool, undergraduate and graduate students have also received numerous national awards including, Barry Goldwater Award, Churchill Scholar (Cambridge), NSF Predoctoral Fellowship, Westinghouse Awards and Nobel Laureate Lindau Meeting award.