CCB special seminar presentation by Dr. Alicia Kowaltowski, Universidade de São Paulo.
See below for further details.
Mitochondrial Respiration, Reactive Oxygen Species and Aging
Alicia J. Kowaltowski
Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo
Mitochondria, in addition to providing most of the ATP necessary to maintain cells alive, also generate significant quantities of free radicals and other reactive oxygen species. Over the years, the accumulation of these species and the modifications they promote to our molecules leads to some of the alterations associated with aging.
Our group studies how mitochondria generate oxidants and their impact on cell and animal survival. We also study interventions, such as calorie restriction and mild mitochondrial uncoupling, that can control the generation of reactive oxygen species by mitochondria and increase lifespan.
Key references (experimental):
Tahara EB, Barros MH, Oliveira GA, Netto LE, Kowaltowski AJ. Dihydrolipoyl dehydrogenase as a source of reactive oxygen species inhibited by caloric restriction and involved in Saccharomyces cerevisiae aging. FASEB J 2007; 21:274-83.
Caldeira da Silva CC, Cerqueira FM, Barbosa LF, Medeiros MH, Kowaltowski AJ. Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity. Aging Cell 2008; 7:552-60.
A recent review:
Kowaltowski AJ, de Souza-Pinto NC, Castilho RF, Vercesi AE. Mitochondria and reactive oxygen species. Free Radic Biol Med 2009; 47:333-43.
tle/abstract to be provided in the near future.