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Faculty Research

Izgu, Enver Cagri

Izgu new profile picture croppedAssistant Professor

Research Synopsis: Synthesis and catalysis of organic molecules. Chemistry of functional polymers of both non-biological and biological nature. Detection and treatment of human disease states.

Phone: (848) 445-4361

E-mail: ec.izgu@rutgers.edu

 

 

 

 

 

 

Selected Publications

Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole-Activated Nucleotides. Li, L., Prywes, N., Tam, C. P., O’Flaherty, D. K., Lelyveld, V. S., Izgu, E. C., Pal, A., and Szostak, J. W. J. Am. Chem. Soc. 2017139, 1810–1813.

Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer-Template Complexes.Tam, C. P., Fahrenbach, A. C., Björkbom, A., Prywes, N., Izgu, E. C., and Szostak, J. W. J. Am. Chem. Soc. 2017139, 571–574.

N-Carboxyanhydride-Mediated Fatty Acylation of Amino Acids and Peptides for Functionalization of the Protocell Membrane. Izgu, E. C., Björkbom, A., Kamat, N. P., Lelyveld, V. S., Zhang, W., Jia, T. Z., and Szostak, J. W. J. Am. Chem. Soc. 2016138, 16669–16676

Synthesis of Activated 3′-Amino-3′-deoxy-2-thio-thymidine, a Superior Substrate for the Nonenzymatic Copying of Nucleic Acid Templates. Izgu, E. C., Oh, S. S. and Szostak, J. W. Chem. Commun. 201652, 3684–3686.

Uncovering the Thermodynamics of Monomer Binding for RNA Replication. Izgu, E. C.,* Fahrenbach, A. C.,* Zhang, N., Li L., Zhang, W.; Blain, C., Larsen, A. T., and Szostak, J. W. J. Am. Chem. Soc. 2015137, 6373–6382.

Total Synthesis of (±)-Leuconolam: Intramolecular Allylic Silane Addition to a Maleimide Carbonyl Group. Izgu, E. C., and Hoye, T. R. Chem. Sci. 20134, 2262–2266.

o-(Trialkylstannyl)anilines and Their Utility in Migita–Kosugi–Stille Cross-Coupling: Direct Introduction of the 2-Aminophenyl Substituent. Izgu, E. C., and Hoye, T. R. Tetrahedron Lett. 201253, 4938–4941. 

Access to Functionalized Steroid Side Chains via Modified Julia Olefination. Izgu, E. C., Burns, A. C., and Hoye, T. R. Org. Lett. 201113, 703–705.

Long-range Shielding Effects in the  H NMR Spectra of Mosher-like Ester Derivatives. Hoye, T. R., Erickson, S. E., Erickson-Birkedahl, S. L., Hale, C. R. H., Izgu, E. C., Mayer, M. J., Notz, P. K., and Renner, M. K. Org. Lett. 2010, 12, 1768–1771.

Catalytic Enantioselective Addition of Diethylzinc to Aldehydes Using Aziridine Based Chiral Ligands. Bulut, A., Aslan, A., Izgu, E. C., and Dogan, O. Tetrahedron: Asymm. 2007, 18, 1013–1016. 

People Page

 

Links

Izgu Research Group

Cancer Institute of New Jersey 

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Wright-Rieman Labs
610 Taylor Road
Piscataway, NJ 08854

 

Main Office Phone:
848.445.8699