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Historical Research

Mechanism of Carbon Dioxide Adsorption in a Highly Selective Porous Coordination Network

Understanding the interactions between adsorbed gas molecules and pore surface at molecular level is vital to rational design and development of gas-selective nanoporous solids, and critical for many important industrial processes.

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Multimodal Core-Shell Nanoparticles for Stem Cell Research

Figure Angewandte Chemie Hot Paper KB 05 08 2013 V4

Understanding the interactions between adsorbed gas molecules and pore surface at molecular level is vital to rational design and development of gas-selective nanoporous solids, and critical for many important industrial processes.

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Olson group unravels long-range communication in chromatin important for gene expression

Long Range Communication on Chromatin Image with caption

Although the genetic messages in DNA are stored in a linear sequence of base pairs, the genomes of living species do not function in a linear fashion.

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Single Vehicular Delivery of siRNA and Small Molecules to Control Stem Cell Differentiation

Single Vehicular Delivery of siRNA 800

Achieving a controlled and reproducible means to direct stem cell differentiation is the single most critical concern scientists have been trying to address since the discovery of stem cells.

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Adaptor proteins

Adaptor proteins are known to function as connecting links between different signaling proteins.

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Enzymes that protect the integrity of the genome

DNA is startlingly prone to chemical damage, by both exogenous and endogenous species.

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PolyMorphine: An innovative biodegradable polymer for extended pain relief

DNA is startlingly prone to chemical damage, by both exogenous and endogenous species.

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Reaction Path and Transition States for RNA Transphosphorylation Models

Understanding the mechanisms underlying the catalytic properties of RNA have applications in the design of new biotechnology, and are also implicated in the evolutionary origins of life itself.

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Reactive Organic Intermediates from Diazirines

New syntheses of the dihalodiazirines permit Professor Robert A. Moss and his group to generate dihalocarbenes by laser flash photolysis (LFP) and to study the fundamental kinetic and energetic properties of highly reactive species that survive for less than milliseconds.

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Single-molecule fluorescence resonance energy transfer defines opening and closing of the RNA polymerase clamp

Single molecule fluorescence resonance energy transfer

Using single-molecule fluorescence resonance energy transfer, Richard H. Ebright and co workers have defined bacterial RNA polymerase (RNAP) clamp conformation at each step in transcription initiation and elongation.

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Structure of molecular machine that initiates transcription

Structure of molecular machine that initiates transcription r

A team of Rutgers CCB researchers led by Richard H. Ebright and Eddy Arnold has determined the three-dimensional structure of the transcription initiation complex, the key intermediate in the process by which cells read out genetic information in DNA.

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Maximizing photosynthesis at low light intensity

Photosynthetic organisms use several strategies to cope with vast solar flux intensity differences based on seasonal changes, time of day and weather conditions.

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Impact of Locally Delivered Salicylic Acid from a Poly(anhydride-ester) on Bone Regeneration in Diabetic Rats

The local and sustained delivery of salicylic acid, a non-steroidal anti-inflammatory drug (NSAID), significantly increased diabetic bone regeneration and accelerated normoglycemic bone regeneration.

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GRAPHENE-NANOPARTICLE for Guiding Stem Cell Differentiation and Neuronal Behaviors

The ability to utilize physical cues such as nanotopographical features, substrate stiffness, geometry, and the dimension of extracellular matrix (ECM) protein patterns to control stem cell fate has great potential in stem cell-based regenerative medicine.

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Design of Polar and Magnetic Materials: In Search of Multifunctional Oxides

Polar oxides are of much interest in materials science and engineering.

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Biohybrid –Se–S– Coupling Reactions of an Amino Acid Derived Seleninate

Professor Spencer Knapp, Zhexun Sun, and Mohannad Abdo describe the synthesis of the N-(2-seleninatoethyl) amide of N-Boc-phenylalanine, serving here as a peptide model, and its click-type reductive coupling reactions under mild protic conditions with unprotected thiouridine and glutathione.

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Biodegradable Ferulic Acid-containing Poly(anhydride-ester): Degradation Products with Controlled Release and Sustained Antioxidant Activity

Ferulic acid is a naturally-ocurring antioxidant and antimicrobial compound used in biomedical and cosmetic formulations to prevent oxidative stress and aging, but suffers from poor stability.

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Binaphtholate Tantalum and Niobium Complexes

BinaphtholateTantalumAndNiobiumComplexesThe hydroamination and hydroaminoalkylation are two atom-economical processes for the synthesis of industrially and pharmaceutically valuable amines.

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Direct conversion of Alkanes to Alkylaromatics

Direct conversions of Alkanes to AlkylaromaticsAromatic hydrocarbons are among the most important building blocks in the chemical industry, used as precursors  for materials as diverse as fuels, detergents, plastics, fibers and pharmaceuticals.

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Cleavage and Formation of C-F Bonds by an Iridium Complex

Cleavage and Formation of C F Bonds by an Iridium Complex fullCatalysis by transition metal complexes is key to the transformations of organic molecules ranging from fuels to fine chemicals.

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Molecules of RNA Form Biological Catalysts

molecules of RNAIt is a fundamental question as to how molecules of RNA, with its limited chemical repertoire of fairly inert nucleotide units, are able to form biological catalysts that can speed up reaction rates by 10 million-fold or more.

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Daniel Seidel’s research highlighted in Chemical & Engineering News

nucleophilic catalysisA recent publication in the Journal of the American Chemical Society (JACS) from the research group of Prof. Daniel Seidel (J. Am. Chem. Soc., 2009, 131 (47), pp 17060–17061) was the subject of a news report in the November 30 issue of Chemical & Engineering News.

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Lanthanide Fluoride Clusters: the most efficient molecular NIR emission sources currently available

jbrennanresearch03The Nd28 cluster pictured here is significant not only because it is the largest lanthanide cluster known, but also because it has the highest NIR quantum efficiency reported for a 'molecular' Nd compound.

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Amyloidogenesis in vitro

DavidTalaga01The study of amyloid structure and growth has been motivated by their implication in many human diseases.

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The First Semiconductor Bulk Material That Emits Direct White Light

JingLiSemiCondMatA unique type of inorganic-organic hybrid semiconductor bulk materials are capable of emitting direct white light.

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DNA structure and interactions

WilmaOlson01Knowledge-based representation of the hydration of the ideal B-DNA double helix based on the known positioning of water molecules around the individual sugars, phosphates, and bases of nucleotides in well resolved crystal structures.

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Alkane metathesis

goldman01Organoiridium complexes catalyze the dehydrogenation of alkanes and alkyl groups, a transformation with tremendous potential applicability.

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Structure of Transcription Initiation Complexes

RichardEbright01Knowledge-based representation of the hydration of the ideal B-DNA double helix based on the known positioning of water molecules around the individual sugars, phosphates, and bases of nucleotides in well resolved crystal structures.

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Protein Data Bank

HelenBerman01Two horse hemoglobin structures (structures 2mhb2 and 2dhb3) are overlaid to show the conformational change that occurs when a ligand is bound to the heme group.

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Transition structure for the enzyme-catalyzed decarboxylation of a nucleic acid

JeehiunLee01Calculations are used to elucidate possible transition structures for enzyme mechanisms.

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Phenylalanine

phenylalaninePhenylalanine forms an aromatic hydrogen bond—an interaction between the pi-electron cloud of an aromatic ring and a hydrogen-bond donor—with cytosine in the [Phe181]CAP-DNA complex.

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Surface chemistry: chlorine induced copper-silicide crystallization on silicon

JaneHinch01A 1300 x 1300Å STM Scanning Tunnelling Microscopy image of an atom-thick Cu2Si layer on a single crystal Si(111) surface.

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