Department of Chemistry and Chemical Biology
The Baum Group

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The Baum Group studies protein-protein interaction and protein aggregation through biochemical and biophysical techniques, including Nuclear Magnetic Resonance.

Baum Group 

News:

March 2024: Mahsa Darestani Farahani joins the Baum group! Welcome!

April 2023: Dr. Abdullah Naiyer has joined the group as a Postdoctoral Associate. Welcome!

January 2023: New CCB graduate students join the Baum group! Welcome Paul and Abuzar!!

November 2022: Our recent paper, "Probing the Effect of Glycosaminoglycan Depletion on Integrin Interactions with Collagen I Fibrils in the Native Extracellular Matrix Environment"  is now published in Protein Science! Great work Jonny!

August 2022: Congratulations to Caitlyn for presenting her poster at ICMRBS 2022!

April 2022: Jonny has successfully defended his PhD! Congratulations!!

Fabruary 2022: We welcome new CCB graduate student, Priscilla!

January 2022: Kristina Kannheiser joins the Baum group! Welcome!

October 2021: Congratulations, Tamr!!! Tamr has successfully defended his PhD! 

October 2021: Check out our recent paper, "DJ-1 Acts as a Scavenger of alpha-Synuclein Oligomers and Restores Monomeric Glycated alpha-Synuclein" now in Biomolecules! Great work Tamr, Jonny, Snow, and Cody!

September 2021: Our work as part of the IQB COVID-19 Boot Camp: "Evolution of the SARS-CoV-2 Proteome in Three Dimensions (3D) During the First 6 Months of the COVID-19 Pandemic" is now published in Proteins: Structure, Function, and Bioinformatics! Congratulations Jon and Andrew!

August 2021: Our recent work on "Molecular Dynamics Analysis of a Flexible Loop at the Binding Interface of the SARS-CoV-2 Spike Protein Receptor-Binding Domain" is now published in Proteins: Structure, Function, and Bioinformatics! Nice work Jon, Baifan, Andrew, and Cody!

August 2021: Congratulations to Jordan, who has been awarded a fellowship through the Biotechnology Training Program! Well done, Jordan!

May 2021: "Tannic Acid Inhibits α-Synuclein Amyloid Fibril Formation via Binding to the Monomer N-terminal Domain" is now available on bioRxiv. Great work Jon S. & Jon W.!

May 2021: Bridget has been awarded an NIH T32 Postdoctoral Fellowship! Congratulations, Bridget!

May 2021: Our recent paper, "NMR unveils an N-terminal interaction interface on acetylated-α-synuclein monomers for recruitment to fibrils,"  is published in PNAS! Great work Snow, Baifan, Cody, and Jon!

April 2021: Bridget Milorey joins the group as a new postdoc! Welcome, Bridget!

January 2021: Our recent MD work in collaboration with Dave Case is now available on bioRxiv: "Molecular Dynamics Analysis of a Flexible Loop at the Binding Interface of the SARS-CoV-2 Spike Protein Receptor-Binding Domain." Good work Jon, Baifan, Andrew, and Cody!

January 2021: Welcome to the group! We welcome new CCB graduate students, Jordan Elliott and Koustav Saha!

August 2020: Our pre-print "Probing acetylated-α-synuclein monomer-aggregate complexes by NMR elucidates mechanism of fibril seeding" is now available on bioRxiv. Congrats Snow, Baifan, and the rest of the team!

June 2020: Rutgers returns to research at a 50% capacity. As always, stay safe and wear a mask!

May 2020: Andrew Sam joins the group as a remote undergrad researcher. Welcome Andrew!

May 2020: We have received special authorization, and work begins to express and study the RBD from the SARS-CoV-2 Spike protein.

April 2020: Congratulations to Caitlyn Tobita who has been accorded an Honorable Mention in the 2020 National Science Foundation (NSF) Graduate Research Fellowship Program (GRFP) competition, a significant national achievement!

March 2020: Working from home begins for the Baum Lab. Stay safe! Wear a mask!

February 2020: Our recent collaboration with Prabhas Moghe's lab, "Antioxidant nanoparticles for concerted inhibition of α-synuclein fibrillization, and attenuation of microglial intracellular aggregation and activation," is published in Frontiers in Bioengineering and Biotechnology!

January 2020: We welcome our new CCB graduate student, Seungwoo Lee!

December 2019: "Collagen I weakly interacts with the β-sheets of β2-microglobulin and enhances conformational exchange to induce amyloid formation" is now published in JACS! Excellent job, team!

December 2019: Snow has successfully defended her PhD! Congratulations, Snow!!

October 2019: Our recent paper "Increased Dynamics of α-Synuclein Fibrils by β-Synuclein Leads to Reduced Seeding and Cytotoxicity" has been accepted in Scientific Reports!  Great work, Snow and Jon!

October 2019: Our collaborative work with the lab of Adam Gormley and others is now in Press at Macromolecules"PET-RAFT and SAXS: High throughput tools to study compactness and flexibility of single-chain polymer nanoparticles." Good work, everyone!

October 2019: Check out our recent work "Collagen I weakly interacts with the β-sheets of β2-microglobulin and enhances conformational exchange to induce amyloid formation" available as a pre-print on bioRxiv! 

September 2019: Our recent collaboration with the lab of Maral Mouradian has been published in Neurobiology of Aging"Apoptosis signaling regulating kinase 1 deletion mitigates the α-synuclein pre-formed fibril propagation model in mice"

August 2019: Our new paper "Molecular underpinnings of integrin binding to collagen mimetic peptides containing vascular Ehlers-Danlos syndrome-associated substitutions" is now in Press at J. Biol. Chem. Nice work everyone!

April 2019: Our new paper with Sheena Radford "Extracellular matrix components modulate different stages in β2-microglobulin amyloid formation" is now in Press at J. Biol. Chem. 

April 2019: Congratulations to Jonathan Stoeber who has been accorded an Honorable Mention in the 2019 National Science Foundation (NSF) Graduate Research Fellowship Program (GRFP) competition, a significant national achievement!

January 2019: Our recent work on "Increased Dynamics of α-Synuclein Fibrils by β-Synuclein Leads to Reduced Seeding and Cytotoxicity" is available as a pre-print on bioRxiv. Check it out!

January 2019: We welcome our new Laboratory Technician, Scott Taylor!

January 2019: Welcome to Caitlyn Tobita and Ben Ashamole, who have joined the group as graduate students!

November 2018: Our new paper "Cryptic binding sites become accessible through surface reconstruction of the type I collagen fibril" is now in Press at Scientific Reports. Nice work, Jie and Cody!

October 2018: The Baum Lab is now located in the brand new Chemistry & Chemical Biology Building!

October 2018: Jie has successfully defended her PhD! Congratulations, Jie!!

September 2018: Our review on the "Interactions between the Intrinsically Disordered Proteins β-Synuclein and α-Synuclein" is now In Press at Proteomics. Nice work Jon and Snow!

May 2018: Ana's paper "Magnesium Activates Microsecond Dynamics to Regulate Integrin-Collagen Recognition" is In Press at Structure. Nice job Ana!

May 2018: "Multi-Pronged Interactions Underlie Inhibition of α-Synuclein Aggregation by β-Synuclein" is now In Press at J. Mol. Biol. Good work everyone!

March 2018: Dr. Baifan Wang has joined the group as a Postdoctoral Associate. Welcome!

January 2018: Jonathan Stoeber joins the group as a new graduate student. Welcome!