Dr. K.Y. Chen's Laboratory - Publications

Publications (1995-1997)

Tao, Y. and Chen, K.Y. Purification of deoxyhypusine synthase from Neurospora crassa to homogeneity by substrate elution affinity chromatography. J. Biol. Chem., 270, 383-386, 1995.

Good, L., Chen, J. and Chen, K.Y. Analysis of sequence specific binding of cis-elements in the human thymidine kinase gene promoter during G1/S phase transition. J. Cell. Physiol.,163, 636-644, 1995.

Huang, E., Carrucio, L., Liu, A.Y. and Chen, K.Y. Rapid activation of the heat shock transcription factor by hypoosmotic stress in mammalian cells. Biochemical J., 307, 347-352, 1995.

Tao, Y. and Chen, K.Y. Molecular cloning and functional expression of Neurospora deoxyhypusine synthase cDNA and identification of yeast ,deoxyhypusine synthase cDNA. J. Biol. Chem., 270, 23984-23987, 1995.

Pang, J.H. and Chen, K.Y. The age-dependent binding of CBP/tk, a CCAAT binding protein, is deregulated in transformed and immortalized mammalian cells but absent in premature aging cells. Experimental Gerontology, 31, 97-109, 1996.

Yan, Y.P., Tao, Y. and Chen, K.Y. Molecular cloning and functional expression of human deoxyhypusine synthase cDNAs based on expressed sequence tag information. Biochem. J., 315, 429-434, 1996.

Good, L.F. and Chen, K.Y. Cell cycle- and age-dependent transcriptional regulation of human thymidine kinase gene: The role of NF-Y in the CBP/tk binding complex. Biol. Signals, 5, 163-169, 1996.

Good, L.F., Dimri, G.P., Campisi, J. and Chen, K.Y. Regulation of dihydrofolate reductase gene expression and E2F components in IMR-90 human diploid fibroblasts during growth and senescence. J. Cell. Physiol.,168, 580-588, 1996.

Chen, Z.P., Yan, Y.P., Ding, Q., Potenza, J.A., Knapp, S., Schugar, H.J. Chen, K.Y. Effects of inhibitors of deoxyhypusine synthase on the differentiation of mouse neuroblastoma and ertthroleukemia cells. Cancer Letters, 105, 233-239, 1996.

Liu, A.Y.-C., Chen, K.Y. and Denhardt, D.T. Transcription Factors and Cell Aging. Biol. Signals, 5, 127-129, 1996.

Chen, Z.P and Chen K.Y. Dramatic attenuation of hypusine formation on eukaryotic initiation factor 5A during senescence of IMR-90 human diploid fibroblasts. J. Cell. Physiol., 170, 248-254, 1997.J. Cell. Physiol., 170, 248-254, 1997.

Chen, Z.P. and Chen, K.Y. Marked elevation of hypusine formation on eukaryotic initiation factor 5A in v-Ha-ras transformed mouse NIH3T3 cells. Cancer Letters, 115, 235-241, 1997.

Liu, Y.P., Nemeroff, M., Yan, Y.P. and Chen, K.Y. Interaction of eukaryotic initiation factor 5A with human immunodeficiency type I virus Rev response element and U6 snRNA requires deoxyhypusine or hypusine modification. Biol. Signals, 6, 166-174, 1997.

Chen, K.Y. and Liu, A.Y.-C. Hypusine formation on eukaryotic initiation factor 5A, biochemistry and function. Biol. Signals, 6, 105-109, 1997.

Caruccio, L., Bae, S., Liu, A.Y-C. And Chen, K.Y. Rapid activation of the heat shock factor, HSF1, by hyper- and hypo-osmotic stress in mammalian cells. Biochemical J., 327, 341-347, 1997.

Chen, K.Y. Transcription factors and the down-regulation of G1/S boundary genes in human diploid fibroblasts during senescence. Frontiers in Bioscience, 2, d417-426, 1997.