Dr. K.Y. Chen's Laboratory - Aging and NF-Y

Cell Aging Publications

Chen, K.Y. and Chang, Z.F. Age dependency of the metabolic conversion of polyamines into amino acids in IMR-90 human embryonic lung diploid fibroblasts. J. Cell. Physiol. 128 ,27-32, 1986.

Liu, A.Y.-C., Chang, Z.F. and Chen, K.Y. Increased cAMP-dependent protein kinase activity in aging human diploid fibroblasts. J. Cell. Physiol. 128, 149-154, 1986.

Chen, K.Y., Chang, Z.F. and Liu, A.Y.-C. Changes of serum-induced ornithine decarboxylase activity and putrescine content during aging of IMR-90 human diploid fibroblasts. J. Cell. Physiol. 129, 142-146, 1986.

Chen, K.Y. and Chang, Z.F. A marked increase of fucosylation of glycoproteins in human diploid fibroblasts (IMR-90) during senescence in vitro Biochem. Biophys. Res. Commun., 142, 767-774, 1987.

Chang, Z.F. and Chen, K.Y. Regulation of ornithine decarboxylase and other cell-cycle dependent genes during senescence of IMR-90 and human fibroblasts. J. Biol. Chem., 263, 11431-11435, 1988.

Chen, K.Y., Chang, Z.F., Pang, J.H, He, G.S., Liu, A.Y.-C. Polyamine metabolism and cell cycle-dependent gene expression in IMR-90 human diploid fibroblasts during senescence in culture. Exp. Gerontol., 24, 523-537, 1989.

Liu, A.Y.-C., Choi, H., Lee, Y. and Chen, K.Y. Molecular events involved in transcriptional activation of heat shock genes become progressively refractory to heat stimulation during aging of human diploid fibroblasts. J. Cellular Physiol. 149, 560-566, 1991.

Pang, J.H and Chen, K.Y. A "CCAAT" binding protein, CBP/tk, may be involved in the regulation of thymidine kinase gene expression in human IMR-90 diploid fibroblasts during senescence. J. Biol. Chem., 268, 2909-2916, 1993.

Pang, J.H. and Chen, K.Y. A global change of expression of G1/S phase genes in IMR-90 human diploid fibroblasts during senescence. J. Cell. Physiol. 160, 531-538, 1994.

Good, L., Chen, J. and Chen, K.Y. Analysis of sequence specific binding of cis-elements in the human thymidine kinase gene promoter during G1/S phase transition. J. Cell. Physiol.,163, 636-644, 1995.

Good, L.F., Dimri, G.P., Campisi, J. and Chen, K.Y. Regulation of dihydrofolate reductase gene expression and E2F components in IMR-90 human diploid fibroblasts during growth and senescence. J. Cell. Physiol.,168, 580-588, 1996.

Pang, J.H. and Chen, K.Y. The age-dependent binding of CBP/tk, a CCAAT binding protein, is deregulated in transformed and immortalized mammalian cells but absent in premature aging cells. Experimental Gerontology, 31, 97-109, 1996.

Liu, A.Y.-C., Chen, K.Y. and Denhardt, D.T. Transcription Factors and Cell Aging. Biol. Signals, 5, 127-129, 1996.

Chen, Z.P and Chen K.Y. Dramatic attenuation of hypusine formation on eukaryotic initiation factor 5A during senescence of IMR-90 human diploid fibroblasts. J. Cell. Physiol., 170, 541-548, 1997.

Chen, K.Y. Transcription factors and the down-regulation of G1/S boundary genes in human diploid fibroblasts during senescence. Frontiers in Bioscience, 2, d417-426, 1997.

Matuoka, K. and Chen, K.Y. Nuclear factor Y (NF-Y) and cellular senescence. Exp. Cell Res., 253, 365-371, 1999.

Lu, J.B., Park, J., Liu, A.Y-C. and Chen, K.Y. Osmotic stress-induced activation of HSF1 DNA binding activity is dramatically attenuated in senescent human cells. J. Cell. Physiol., 184, 183-190, 2000.

Matuoka, K. and Chen, K.Y. Possible role of subunit A of nuclear factor Y (NF-Y) in normal human diploid fibroblasts during senescence. Biogerontology, 1, 261-271, 2000.

Matuoka K. Chen KY., Takenawa. Rapid reversion of aging phenotypes by nicotinamide through possible modulation of histone acetylation. Cell Mol Life Sci. 2108-2116. 2001.

Matuoka, K. and Chen, K.Y. Telomerase positive human diploid fibroblasts are resistant to replicative senescence but not premature senescence induced by chemical reagents. Biogerontology, 3, 365-372, 2002.

Matuoka K. chen KY. Transcriptional regulation of cellular ageing by the CCAAT boxbinding factor CBF/ NF-Y. Ageing Res rev. 639 - 651. 2002

Matuoka, K., Chen, K.Y. and Takenawa, T. A positive role of phosphatidylinositol 3-kinase in aging phenotype expression in cultured human diploid fibroblasts. Archives Gerontology and Geriatrics, 36, 203-219, 2003.