Dr. K.Y. Chen's Laboratory - Polyamines

Polyamines Publications

Wang, K.T., Chen, K.Y. and Weinstein, B. Amino acids and peptides XV. Separation of N-benzyloxycarbonyl amino acids and esters. J. Chromatog., 32, 591-592, 1968.

Chen, K.Y., Heller, J.S. and Canellakis, E.S. The inhibition of the induction of ornithine decarboxylase by cations. Biochem., Biophys. Res. Commun., 70, 212-219, 1976.

Chen, K.Y., Heller, J.S. and Canellakis, E.S. Studies on the regulation of ornithine decarboxylase activity by the microtubules: The effect of colchicine and vinblastine. Biochem. Biophys. Res. Commun., 68, 401-408, 1976.

Chen, K.Y. and Canellakis, E.S. Enzyme regulation in neuroblastoma cells in a salts-glucose medium: The induction of ornithine decarboxylase by asparagine and glutamine. Proc. Natl. Acad. Sci., USA 74, 3791-3795,1977.

Canellakis, E.S., Heller, J.S., Kyriakidis, D. and Chen, K.Y. The intracellular levels of ornithine decarboxylase, its half-life and a hypothesis relating polyamine sensitive membrane receptors to growth. Adv. Polyamine Res., 1, 17-30, 1978.

Heller, J.S., Chen, K.Y., Wong, W.F. and Canellakis, E.S. The modulation of the induction of ornithine decarboxylase by spermine, spermidine and diamines. J. Cell. Physiol., 96, 225-234, 1978.

Chen, K.Y. Differences in the mode of regulation of ornithine decarboxylase activity in undifferentiated versus differentiated mouse N18 neuroblastoma cells. FEBS Letters, 119, 307-311, 1980.

Chen, K.Y. and Rinehart, C.A., Jr. Difference in putrescine transport in undifferentiated versus differentiated mouse NB-15 neuroblastoma cells. Biochem. Biophys. Res. Commun., 101, 243-249, 1981.

Chen, K.Y., Prespe, V., Parken, N. and Liu, A.Y.-C. Change of ornithine decarboxylase activity and polyamine contents upon differentiation of mouse NB-15 euroblastoma cells. J. Cell. Physiol., 110, 258-290, 1982.

Chen, K.Y. and Liu, A.Y.-C. The role of polyamines in the differentiation of mouse neuroblastoma cells. Adv. Polyamine Res., 4, 743-755, 1983.

Chen, K.Y., Nau, D. and Liu, A.Y.-C. Effect of inhibitors of ornithine decarboxylase on the differentiation of mouse neuroblastoma cells. Cancer Res., 43, 2812-2818, 1983.

Chen, K.Y. Transglutaminase catalyzed incorporation of putrescine into surface proteins of mouse neuroblastoma cells. Molecular and Cellular Biochemistry, 58, 91-98, 1984.

Chen, K.Y. and Verma, R. Spermine specifically inhibits the phosphorylation of an 11,000-dalton nuclear protein in various cultured mammalian cell lines. Biochem. Biophys. Res. Commun., 118, 710-716,1984.

Rinehart, C.A., Jr. and Chen, K.Y. Characterization of the polyamine transport system in mouse neuroblastoma cells: Effects of sodium and system A amino acids. J. Biol. Chem., 259, 4750-4756, 1984.

Chen, K.Y. and Martynowicz, H. Lack of detectable polyamines in an extremely halophilic bacterium. Biochem. Biophys. Res. Commun. 124, 423-429, 1984.

Verma, R. and Chen, K.Y. Spermine inhibits the phosphorylation of the11,000- and 10,000-dalton nuclear proteins catalyzed by nuclear kinase NI in NB-15 mouse neuroblastoma cells. J. Biol. Chem. 261, 2890-2896, 1986.

Chen, K.Y. and Chang, Z.F. Age dependency of the metabolic conversion of polyamines into amino acids in IMR-90 human embryonic lung diploid fibroblasts. J. Cell. Physiol. 128, 27-32, 1986.

Chen, K.Y., Chang, Z.F. and Liu, A.Y.-C. Changes of serum-induced ornithine decarboxylase activity and putrescine content during aging of IMR-90 human diploid fibroblasts. J. Cell. Physiol. 129, 142-146, 1986.

Chang, Z.F. and Chen, K.Y. Regulation of ornithine decarboxylase and other cell-cycle dependent genes during senescence of IMR-90 and human fibroblasts. J. Biol. Chem., 263, 11431- 11435, 1988.

Chen, K.Y., Chang, Z.F., Pang, J.H, He, G.S., Liu, A.Y.-C. Polyamine metabolism and cell cycle-dependent gene expression in IMR-90 human diploid fibroblasts during senescence in culture. Exp. Gerontol., 24, 523-537, 1989.

Chen, Z.P. and Chen, K.Y. Differentiation of a mouse neuroblastoma variant cell line whose ornithine decarboxylase gene has been amplified. Biochim. Biophys. Acta, 1133, 1-8, 1991.

Chen, Z.P. and Chen, K.Y. Mechanism of regulation of ornithine decarboxylase gene expression in a variant mouse neuroblastoma cell line. J. Biol. Chem. 267, 6946-6951, 1992.

Chen, Z.P. and Chen, K.Y. A marked difference in the effect of asparagine on the regulation of ornithine decarboxylase gene expression in NIH 3T3 and ras-transformed NIH 3T3 cells. Cancer Letters, 86, 97-103, 1994.