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Dr. Qian Cai, Rutgers University
Friday, March 22, 2019, 11:00am - 12:00pm

Qian Cai PicAxonal Transport and Mitochondrial Quality Control in Alzheimer’s Disease

The focus of our current research is on elucidating the mechanisms regulating axonal transport, membrane trafficking and organelle function and their impact on neuronal homeostasis in health and axonal degeneration.

Mitochondrial dysfunction is a hallmark in neurodegenerative diseases, including Alzheimer’s disease (AD). Accumulation of pathologically phosphorylated tau is known to cause mitochondrial damage, contributing to neurodegeneration in AD. Mitophagy, a cargo-specific autophagy, constitutes a key mechanism of mitochondrial quality control that involves sequestration of defective mitochondria into autophagosomes for lysosomal degradation. However, the details of the intersection of tau-mediated mitochondrial defects and mitophagy remain unclear. In my talk, I will discuss the mechanism of mitophagy regulation and its impact on tauopathy-linked synaptic deficits drug delivery system concomitantly with technology that facilitates the release of the nanocarrier from the circulation into the tumor organ. 

~ Coffee/tea will be served prior to lecture~

Location CCB Room 3217
Hosted by Professor KiBum Lee