“Photo-Control of Proteins”
The design of proteins whose structure and activity can be manipulated using light can lead to a better understanding of how natural protein switches function and can also lead to the creation of powerful tools for manipulating complex biological systems in vivo. We have taken two approaches to designing photo-controlled proteins: one that couples a photo-isomerizable small molecule (typically azobenzene) to a protein to drive a conformational change, and a second that uses phage display methods to engineer interactions with natural photo-switchable proteins. I will present recent results and describe pros and cons of each approach.
~Coffee/tea will be served prior to lecture~