BEGIN:VCALENDAR VERSION:2.0 PRODID:-//jEvents 2.0 for Joomla//EN CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VEVENT UID:a81333ef50ab534a7335eed41c279216 CATEGORIES:Colloquium CREATED:20170816T180722 SUMMARY:Fall 2017 Colloquium: Professor Brian Callahan DESCRIPTION:
Tue sday October 24, 2017
Wright-Reiman Labs Room 260
"Protein Steroylation; Catalysis and Applic ation"
Covalent modification of proteins by sterols represents one of the rarest forms of
post-translational modification. In t he entire human proteome, with > 30,000 polypeptides, the total number o f sterol-modified proteins stands at 3, and these three proteins make-up th e so-called hedgehog family. Hedgehog proteins attract fundament al interest as cell-cell signaling factors during animal development, as we ll as oncogenic growth factors in multiple cancers. In both cont exts, hedgehog function appears to depend on covalent steroylation. p>
In this talk, I will describe our recent efforts to probe the molecula r mechanism of sterol modification, to manipulate the process with small mo lecules, and to apply the chemistry toward the emerging field of bioconjuga tion.
~Coffee/tea will be served prior to lecture~ strong>
X-ALT-DESC;FMTTYPE=text/html:Tuesday October 24, 2017
Wrigh t-Reiman Labs Room 260
"Protein Steroylat ion; Catalysis and Application"
Covalent modification of proteins by sterols represents one of the rarest forms of
post-translational modi fication. In the entire human proteome, with > 30,000 polypep tides, the total number of sterol-modified proteins stands at 3, and these three proteins make-up the so-called hedgehog family. Hedgehog p roteins attract fundamental interest as cell-cell signaling factors during animal development, as well as oncogenic growth factors in multiple cancers . In both contexts, hedgehog function appears to depend on coval ent steroylation.
In this talk, I will describe our recent effo rts to probe the molecular mechanism of sterol modification, to manipulate the process with small molecules, and to apply the chemistry toward the eme rging field of bioconjugation.
~Coffee/tea will be served prior to lecture~
DTSTAMP:20240328T122816 DTSTART:20171024T150000 DTEND:20171024T160000 SEQUENCE:0 TRANSP:OPAQUE END:VEVENT END:VCALENDAR