BEGIN:VCALENDAR VERSION:2.0 PRODID:-//jEvents 2.0 for Joomla//EN CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VEVENT UID:134e73bc79e527a30b0430c844134ce5 CATEGORIES:Colloquium CREATED:20190917T152333 SUMMARY:Professor Jinglin Fu LOCATION:CCB Auditorium (1303) DESCRIPTION:
"DNA Nan ostructures-Templated Proximity Assembly and Confinement of < strong>Biochemical Reactions"
C ellular functions rely on a series of organized and regulated multienzyme c ascade reactions. The catalytic efficiency of multienzyme complexes depends on the spatial organization of composite components which are precisely co ntrolled to facilitate substrate transport and regulate activities. If thes e cellular mechanisms can be mimicked and translated to a non-living artifi cial system, it can be useful in a broad range of applications that will br ing significant scientific and economic impact. Self-assembled DNA nanostru ctures are promising to organize biomolecular components into prescribed, m ulti-dimensional patterns. Here, we described a robust strategy for DNA-sca ffolded assembly and confinement of biochemical reactions. DNA nanostructur es are exploited to organize spatial arrangements of multienzyme cascades w ith control over their relative distance, substrate diffusion paths, compar tmentalization and functional actuation. The combination of addressable DNA assembly and multienzyme cascades promises to deliver breakthroughs toward the engineering of novel biomimetic reactors, which have great potential f or broad applications from chemical synthesis, functional biomaterials and biofuel production to therapeutics and diagnosis.
Selected Re ferences
~Coffee/tea will be served prior to lecture~
X-ALT-DESC;FMTTYPE=text/html:"DNA Nanostructures-Templated Proximity Assembly and Confi nement of Biochemical Reactions"
Cellular functions rely on a series of organized an d regulated multienzyme cascade reactions. The catalytic efficiency of mult ienzyme complexes depends on the spatial organization of composite componen ts which are precisely controlled to facilitate substrate transport and reg ulate activities. If these cellular mechanisms can be mimicked and translat ed to a non-living artificial system, it can be useful in a broad range of applications that will bring significant scientific and economic impact. Se lf-assembled DNA nanostructures are promising to organize biomolecular comp onents into prescribed, multi-dimensional patterns. Here, we described a ro bust strategy for DNA-scaffolded assembly and confinement of biochemical re actions. DNA nanostructures are exploited to organize spatial arrangements of multienzyme cascades with control over their relative distance, substrat e diffusion paths, compartmentalization and functional actuation. The combi nation of addressable DNA assembly and multienzyme cascades promises to del iver breakthroughs toward the engineering of novel biomimetic reactors, whi ch have great potential for broad applications from chemical synthesis, fun ctional biomaterials and biofuel production to therapeutics and diagnosis.< /p>
Selected References
~ Coffee/tea will be served prior to lecture~
X-EXTRAINFO:Hosted by Professor Lu Wang DTSTAMP:20240329T150016 DTSTART:20191119T160000 DTEND:20191119T170000 SEQUENCE:0 TRANSP:OPAQUE END:VEVENT END:VCALENDAR