BEGIN:VCALENDAR VERSION:2.0 PRODID:-//jEvents 2.0 for Joomla//EN CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VEVENT UID:135b3c22d38930d10ef18f0d675ad1db CATEGORIES:Colloquium CREATED:20200114T193029 SUMMARY:Professor Hansang Cho, UNC LOCATION:CCB Auditorium (1303) DESCRIPTION:
3D Human Brain Models in Microfluidics for the Study of N eurological Disorders
With hundreds of b illions of neurons and thousands of trillions of synaptic connections betwe en them, the human brain is the most complex system on earth. However, ther e are no well-developed human brain models to study the brain activities in either laboratory environments or in animal bodies. Here, I present micro- scaled 3D environments that reconstruct a 3D human brain in Alzheimer’s dis ease (AD) by recapitulating AD signature of elevated levels of amyloid-beta (A-beta), tau proteins, activation of microglia, immune cells resident in a central nervous system (CNS), and consequent neuronal damage. In particul ar, the model mirrored microglial neurotoxic activities such as axonal clea vage and neurotoxic release.
~Coffee/tea will be ser ved prior to lecture~
X-ALT-DESC;FMTTYPE=text/html:3D Human Brain Models in Microfl uidics for the Study of Neurological Disorders
With hundreds of billions of neurons and thousands of trillions of s ynaptic connections between them, the human brain is the most complex syste m on earth. However, there are no well-developed human brain models to stud y the brain activities in either laboratory environments or in animal bodie s. Here, I present micro-scaled 3D environments that reconstruct a 3D human brain in Alzheimer’s disease (AD) by recapitulating AD signature of elevat ed levels of amyloid-beta (A-beta), tau proteins, activation of microglia, immune cells resident in a central nervous system (CNS), and consequent neu ronal damage. In particular, the model mirrored microglial neurotoxic activ ities such as axonal cleavage and neurotoxic release.
~Coffee/tea will be served prior to lecture~
X-EXTRAINFO:Hosted by Professor KiBum Lee DTSTAMP:20240329T051730 DTSTART:20200128T160000 DTEND:20200128T170000 SEQUENCE:0 TRANSP:OPAQUE END:VEVENT END:VCALENDAR