BEGIN:VCALENDAR VERSION:2.0 PRODID:-//jEvents 2.0 for Joomla//EN CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VEVENT UID:54843dd1fd0f5f4c099e8c363e03bd21 CATEGORIES:Colloquium CREATED:20200723T153950 SUMMARY:Professor Enver Izgu, Rutgers University DESCRIPTION:
Reactivity-Guided Designs of New Molecular Probes and Cell Surfaces
Our ability to explore aberrant metabolic pathways and pathogenesis remains lim ited, as the majority of current investigative methods interfere with nativ e cellular processes. Although there has been significant progress in desig ning chemical probes, target-specific approaches that use a cell’s own meta bolism are necessary to study cell physiology. Based on this notion, we are establishing an exciting new platform of small molecules and nucleic acids to elucidate disease initiation and progression in live cells. This platfo rm is highly configurable, allowing cytocompatible detection of a wide rang e of biological markers, including enzymes or reactive metabolites, both in organic and organic.
In conjunction to o ur work with new bioimaging and diagnostic tools, we are interested in enca psulating cells with synthetic layers that have characteristics beyond the natural traits of cell membranes. The realization of these cell-in-shell hy brids would push the boundaries of biotechnology, yet current techniques fo r cell surface modification often induce cell death or cause the cells to l ose critical functions pertaining to regulation, signaling, and motility. O ur approach utilizes the inherent reactivity of designer catechols in uniqu e ways to encapsulate cells without disrupting their homeostasis. We aim to harness this bioorthogonal chemistry to increase cellular tolerance to env ironmental conditions or control cell behavior.
In this talk, I will summarize the related advances in cellular ima ging and cell surface modifications and describe how far our lab has come t o advance these fields.
Meeting Link: https://ru
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Reactiv ity-Guided Designs of New Molecular Probes and Cell Surfaces
Our ability to explore aberrant metabolic pathways and pathogenesis remains limited, as the majority of current investigative met hods interfere with native cellular processes. Although there has been sign ificant progress in designing chemical probes, target-specific approaches t hat use a cell’s own metabolism are necessary to study cell physiology. Bas ed on this notion, we are establishing an exciting new platform of small mo lecules and nucleic acids to elucidate disease initiation and progression i n live cells. This platform is highly configurable, allowing cytocompatible detection of a wide range of biological markers, including enzymes or reac tive metabolites, both inorganic and organic.
In conjunction to our work with new bioimaging and diagnostic tools, we are interested in encapsulating cells with synthetic layers that have ch aracteristics beyond the natural traits of cell membranes. The realization of these cell-in-shell hybrids would push the boundaries of biotechnology, yet current techniques for cell surface modification often induce cell deat h or cause the cells to lose critical functions pertaining to regulation, s ignaling, and motility. Our approach utilizes the inherent reactivity of de signer catechols in unique ways to encapsulate cells without disrupting the ir homeostasis. We aim to harness this bioorthogonal chemistry to increase cellular tolerance to environmental conditions or control cell behavior.
In this talk, I will summarize the related advances in cellular imaging and cell surface modifications and describe h ow far our lab has come to advance these fields.
Meeting Link:&nbs
p; https://rutgers.webex.com/rutgers/j.php?MTID=mfe975c45aeedfc
4f09bb0bf17eea5eb7
Meeting number:&nbs
p;120 154 5223
Password: Q9De3Px4RTM