BEGIN:VCALENDAR VERSION:2.0 PRODID:-//jEvents 2.0 for Joomla//EN CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VEVENT UID:38bae35f3849703ddc0bb7b921f0ec92 CATEGORIES:Colloquium CREATED:20210927T164610 SUMMARY:Professor Eva-Maria Strauch, University of Georgia DESCRIPTION:
Targeting Viral Surface Glycoprotei ns
Viral surface glycopro teins provide a powerful way to train the immune system to be prepared for a given virus. Elegant studies have demonstrated how stabilization of these metastable proteins can be undertaken. However, efforts were largely perfo rmed manually and step-by-step. We have incorporated several of these molec ular strategies into systematic automation protocols to stabilize viral sur face proteins while paying close attention to their molecular functionaliti es. Using our approach, we have generated a stabilized version for instance for fusion protein of RSV, rivaling the clinical candidate. We can provide further preliminary data on human metapneumovirus (hMPV) and SARS CoV-2 as model systems which both are otherwise highly instable. We will also short ly discuss potential therapeutic approaches for treatment of viral infectio ns through targeting of intermediate states, as well as a new approach for the generation of protein-protein interactions using neural networks.
Hosted by Professor Sagar Khare
For Zoom meeting information, please
contact Loretta Lupo @
  ;
X-ALT-DESC;FMTTYPE=text/html:Targeting Viral Surface Glycoproteins
Viral surface glycoproteins provide a powerful way to train the immune s ystem to be prepared for a given virus. Elegant studies have demonstrated h ow stabilization of these metastable proteins can be undertaken. However, e fforts were largely performed manually and step-by-step. We have incorporat ed several of these molecular strategies into systematic automation protoco ls to stabilize viral surface proteins while paying close attention to thei r molecular functionalities. Using our approach, we have generated a stabil ized version for instance for fusion protein of RSV, rivaling the clinical candidate. We can provide further preliminary data on human metapneumovirus (hMPV) and SARS CoV-2 as model systems which both are otherwise highly ins table. We will also shortly discuss potential therapeutic approaches for tr eatment of viral infections through targeting of intermediate states, as we ll as a new approach for the generation of protein-protein interactions usi ng neural networks.
Hosted by Professor Sagar Khare
For Zoom me
eting information, please contact Loretta Lupo @
DTSTAMP:20240328T132152 DTSTART:20211130T160000 DTEND:20211130T170000 SEQUENCE:0 TRANSP:OPAQUE END:VEVENT END:VCALENDAR