BEGIN:VCALENDAR VERSION:2.0 PRODID:-//jEvents 2.0 for Joomla//EN CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VEVENT UID:7bf86f3e8bda3340411412254ad26149 CATEGORIES:Colloquium CREATED:20220106T160539 SUMMARY:Dr. David Miller, California Institute of Technology DESCRIPTION:
Natural Inspirat ion in Catalysis
Chemistry and biology have mutually informed and advanced each other; research at the int ersection of these fields has been particularly fruitful for catalysis. My talk will illustrate how enzymes have inspired new advances in synthetic ch emistry, both through biomimicry and by developing new biocatalysts which p erform new-to-nature chemical transformations. Proton-coupled electron tran sfers (PCETs) are critical elementary steps in numerous biological redox pr ocesses. I will discuss how my work has repurposed PCETs to address longsta nding challenges in the catalytic homolysis of strong N–H bonds. I will als o discuss how insights from enzymatic mechanisms can be applied to the disc overy of new-to-nature biocatalytic activities, which can be subsequently o ptimized by directed evolution. Using this approach, the exquisite selectiv ities of enzymes can be applied to challenging reactions such as asymmetric [1,2]-Stevens rearrangements.
Hosted by Professor Jeehi un Lee
For Zoom meeting information, please contact Loretta Lupo @&nb
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Natural Inspiration in Catalysis
Chemistry and biology have mutually informed and advanced each o ther; research at the intersection of these fields has been particularly fr uitful for catalysis. My talk will illustrate how enzymes have inspired new advances in synthetic chemistry, both through biomimicry and by developing new biocatalysts which perform new-to-nature chemical transformations. Pro ton-coupled electron transfers (PCETs) are critical elementary steps in num erous biological redox processes. I will discuss how my work has repurposed PCETs to address longstanding challenges in the catalytic homolysis of str ong N–H bonds. I will also discuss how insights from enzymatic mechanisms c an be applied to the discovery of new-to-nature biocatalytic activities, wh ich can be subsequently optimized by directed evolution. Using this approac h, the exquisite selectivities of enzymes can be applied to challenging rea ctions such as asymmetric [1,2]-Stevens rearrangements.
Hosted by Professor Jeehiun Lee
For Zoom meeting information, please
contact Loretta Lupo @