Cationic amphiphilic macromolecules were complexed with liposomal delivery systems to encapsulate and efficiently deliver siRNA in response to a decrease in endosomal pH and silence target genes with minimal cytotoxicity.


Gu, L; Nusblat, LM; Tishbi; N; Noble, SC; Pinson, CM; Mintzer, E; Roth, CM, Uhrich, KE “Cationic Amphiphilic Macromolecule (CAM)-lipid Complexes for Efficient siRNA Gene Silencing”, J Control Rel, 184 (28) 28-35 (2014). 10.1016/j.jconrel.2014.04.005  PMCID: PMC4090228


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Alysha Moretti


Year of Research Highlight: 2014