The Baum Group studies protein-protein interaction and protein aggregation through biochemical and biophysical techniques, including Nuclear Magnetic Resonance.
May 2021: "Tannic Acid Inhibits α-Synuclein Amyloid Fibril Formation via Binding to the Monomer N-terminal Domain" is now available on bioRxiv. Great work Jon S. & Jon W.!
May 2021: Bridget has been awarded an NIH T32 Postdoctoral Fellowship! Congratulations, Bridget!
May 2021: Our recent paper, "NMR unveils an N-terminal interaction interface on acetylated-α-synuclein monomers for recruitment to fibrils," is published in PNAS! Great work Snow, Baifan, Cody, and Jon!
April 2021: Bridget Milorey joins the group as a new postdoc! Welcome, Bridget!
January 2021: Our recent MD work in collaboration with Dave Case is now available on bioRxiv: "Molecular Dynamics Analysis of a Flexible Loop at the Binding Interface of the SARS-CoV-2 Spike Protein Receptor-Binding Domain." Good work Jon, Baifan, Andrew, and Cody!
January 2021: Welcome to the group! We welcome new CCB graduate students, Jordan Elliott and Koustav Saha!
August 2020: Our pre-print "Probing acetylated-α-synuclein monomer-aggregate complexes by NMR elucidates mechanism of fibril seeding" is now available on bioRxiv. Congrats Snow, Baifan, and the rest of the team!
June 2020: Rutgers returns to research at a 50% capacity. As always, stay safe and wear a mask!
May 2020: Andrew Sam joins the group as a remote undergrad researcher. Welcome Andrew!
May 2020: We have recieved special authorization, and work begins to express and study the RBD from the SARS-CoV-2 Spike protein.
April 2020: Congratulations to Caitlyn Tobita who has been accorded an Honorable Mention in the 2020 National Science Foundation (NSF) Graduate Research Fellowship Program (GRFP) competition, a significant national achievement!
March 2020: Working from home begins for the Baum Lab. Stay safe! Wear a mask!
February 2020: A pre-print of our recent work "Depletion of glycosaminoglycan decreases contact stiffness of single collagen I fibrils in aqueous solution" is available on bioRxiv. Great work Jonny!
February 2020: Our recent collaboration with Prabhas Moghe's lab, "Antioxidant nanoparticles for concerted inhibition of α-synuclein fibrillization, and attenuation of microglial intracellular aggregation and activation," is published in Frontiers in Bioengineering and Biotechnology!
January 2020: We welcome our new CCB graduate student, Seungwoo Lee!
December 2019: "Collagen I weakly interacts with the β-sheets of β2-microglobulin and enhances conformational exchange to induce amyloid formation" is now published in JACS! Excellent job, team!
December 2019: Snow has successfully defended her PhD! Congratulations, Snow!!
October 2019: Our recent paper "Increased Dynamics of α-Synuclein Fibrils by β-Synuclein Leads to Reduced Seeding and Cytotoxicity" has been accepted in Scientific Reports! Great work, Snow and Jon!
October 2019: Our collaborative work with the lab of Adam Gormley and others is now in Press at Macromolecules: "PET-RAFT and SAXS: High throughput tools to study compactness and flexibility of single-chain polymer nanoparticles." Good work, everyone!
October 2019: Check out our recent work "Collagen I weakly interacts with the β-sheets of β2-microglobulin and enhances conformational exchange to induce amyloid formation" available as a pre-print on bioRxiv!
September 2019: Our recent collaboration with the lab of Maral Mouradian has been published in Neurobiology of Aging: "Apoptosis signaling regulating kinase 1 deletion mitigates the α-synuclein pre-formed fibril propagation model in mice".
August 2019: Our new paper "Molecular underpinnings of integrin binding to collagen mimetic peptides containing vascular Ehlers-Danlos syndrome-associated substitutions" is now in Press at J. Biol. Chem. Nice work everyone!
April 2019: Our new paper with Sheena Radford "Extracellular matrix components modulate different stages in β2-microglobulin amyloid formation" is now in Press at J. Biol. Chem.
April 2019: Congratulations to Jonathan Stoeber who has been accorded an Honorable Mention in the 2019 National Science Foundation (NSF) Graduate Research Fellowship Program (GRFP) competition, a significant national achievement!
January 2019: Our recent work on "Increased Dynamics of α-Synuclein Fibrils by β-Synuclein Leads to Reduced Seeding and Cytotoxicity" is available as a pre-print on bioRxiv. Check it out!
January 2019: We welcome our new Laboratory Technician, Scott Taylor!
January 2019: Welcome to Caitlyn Tobita and Ben Ashamole, who have joined the group as graduate students!
November 2018: Our new paper "Cryptic binding sites become accessible through surface reconstruction of the type I collagen fibril" is now in Press at Scientific Reports. Nice work, Jie and Cody!
October 2018: The Baum Lab is now located in the brand new Chemistry & Chemical Biology Building!
October 2018: Jie has successfully defended her PhD! Congratulations, Jie!!
September 2018: Our review on the "Interactions between the Intrinsically Disordered Proteins β-Synuclein and α-Synuclein" is now In Press at Proteomics. Nice work Jon and Snow!
May 2018: Ana's paper "Magnesium Activates Microsecond Dynamics to Regulate Integrin-Collagen Recognition" is In Press at Structure. Nice job Ana!
May 2018: "Multi-Pronged Interactions Underlie Inhibition of α-Synuclein Aggregation by β-Synuclein" is now In Press at J. Mol. Biol. Good work everyone!
March 2018: Dr. Baifan Wang has joined the group as a Postdoctoral Associate. Welcome!
January 2018: Jonathan Stoeber joins the group as a new graduate student. Welcome!