Selected Collagen Publications:
Roth, J., C.L. Hoop, J.K. Williams, R. Hayes, and J. Baum. “Probing the Effect of Glycosaminoglycan Depletion on Integrin Interactions with Collagen I Fibrils in the Native Extracellular Matrix Environment.” Protein Science. 32:e4508 (2022). doi:10.1002/pro.4508
Hoop, C.L., J. Zhu, S. Bhattacharya, C.A. Tobita, S.E. Radford, and J. Baum. "Collagen I Weakly Interacts with the β-sheets of β2-Microglobulin and Enhances Conformational Exchange to Induce Amyloid Formation." J. Am. Chem. Soc. 142:1321-1331 (2020). doi: 10.1021/jacs.9b10421
Hoop, C.L., A.P. Kemraj, B. Wang, S. Gahlawat, M. Godesky, J. Zhu, H.R. Warren, D.A. Case, D.I. Shreiber, and J. Baum. "Molecular Underpinnings of Integrin Binding to Collagen-Mimetic Peptides Containing Vascular Ehlers-Danlos Syndrome-Associated Substitutions." J. Biol. Chem. 294:14442-14453 (2019). doi: 10.1074/jbc.RA119.009685
Benseny-Cases, N., T.K. Karamanos, C.L. Hoop, J. Baum, and S.E. Radford. "Extracelllular Matrix Components Modulate Different Stages of β2-Microglobulin Amyloid Formation." J. Biol. Chem. 294:9392-9401 (2019). doi: 10.1074/jbc.RA119.008300
Zhu, J., C.L. Hoop, D.A. Case, and J. Baum. "Cryptic Binding Sites Become Accessible Through Surface Reconstruction of the Type I Collagen Fibril." Scientific Reports. 8:16646 (2018). doi:10.1038/s41598-018-34616-z
Nunes, A.M., C.A.S.A. Minetti, D.P. Remeta, and J. Baum. "Magnesium Activates Microsecond Dynamics to Regulate Integrin-Collagen Recognition." Structure. 26:1080-1090 (2018). doi:10.1016/j.str.2018.05.010
Hoop, C.L., J. Zhu, A.M. Nunes, D.A. Case, and J. Baum. "Revealing Accessibility of Cryptic Protein Binding Sites within the Functional Collagen Fibril." Biomolecules. 7:76 (2017). doi:10.3390/biom7040076
An, B., S.-W. Chang, C. Hoop, J. Baum, M.J. Buehler, and D.L. Kaplan. “Structural Insights into the Glycine Pair Motifs in Type III Collagen.” ACS Biomater. Sci. Eng. 3:269–278 (2017). doi:10.1021/acsbiomaterials.6b00512
Nunes, A.M., J. Zhu, J. Jezioro, C.A.S.A. Minetti, D.P. Remeta, R.W. Farndale, S.W. Hamaia, and J. Baum. “Intrinsic Local Destabilization of the C-Terminus Predisposes Integrin α1 I Domain to a Conformational Switch Induced by Collagen Binding.” Protein Science. 25:1672–1681 (2016). doi:10.1002/pro.2972
Fu, I., D.A. Case, and J. Baum. “Dynamic Water-Mediated Hydrogen Bonding in a Collagen Model Peptide.” Biochemistry. 54:6029–6037 (2015). doi:10.1021/acs.biochem.5b00622
Xiao, J., X. Sun, B. Madhan, B. Brodsky, and J. Baum. “NMR Studies Demonstrate a Unique AAB Composition and Chain Register for a Heterotrimeric Type IV Collagen Model Peptide Containing a Natural Interruption Site.” J. Biol. Chem. 290:24201–24209 (2015). doi:10.1074/jbc.M115.654871
Xiao, J., Z. Yang, X. Sun, R. Addabbo, and J. Baum. “Local Amino Acid Sequence Patterns Dominate the Heterogeneous Phenotype for the Collagen Connective Tissue Disease Osteogenesis Imperfecta Resulting from Gly Mutations.” J. Struct. Biol. 192:127–137 (2015). doi:10.1016/j.jsb.2015.05.002
Parmar, A.S., A.M. Nunes, J. Baum, and B. Brodsky. “A Peptide Study of the Relationship Between the Collagen Triple-Helix and Amyloid.” Biopolymers. 97:795–806 (2012). doi:10.1002/bip.22070
Selected α/β-Synuclein Publications:
Atieh T.B., J. Roth, X. Yang, C.L. Hoop, and J. Baum. "DJ-1 Acts as a Scavenger of alpha-Synuclein Oligomers and Restores Monomeric Glycated alpha-Synuclein." Biomolecules (2021). doi:10.3390/biom11101466
Stoeber, J., J.K. Williams, P.V. Moghe, and J. Baum. "Tannic Acid Inhibits a-Synuclein Amyloid Fibril Formation via Binding to the Monomer N-terminal Domain." bioRxiv. (2021). doi:10.1101/2021.05.26.445860
Yang, X., B. Wang, C.L. Hoop, J.K. Williams, and J. Baum. "NMR Unveils an N-terminal Interaction Interface on Acetylated-α-synuclein Monomers for Recruitment to Fibrils." Proc. Natl. Acad. Sci. USA. (2021). doi:10.1073/pnas.2017452118
Zhao, N., X. Yang, H.R. Calvelli, Y. Cao, N.L. Francis, R.A. Chmielowski, L.B. Joseph, Z.P. Pang, K.E. Uhrich, J. Baum, and P.V. Moghe. "Antioxidant Nanoparticles for Concerted Inhibition of α-Synuclein Fibrillization, and Attenuation of Microglial Intracellular Aggregation and Activation." Frontiers in Bioengineering and Biotechnology. 8: 112 (2020). doi:10.3389/fbioe.2020.00112
Zhang, J., E.S. Park, H.-J. Park, R. Yan, M. Grudniewska, X. Zhang, S. Oh, X. Yang, J. Baum, and M.M. Mouradian. "Apoptosis Signal Regulating Kinase 1 Deletion Mitigates the α-Synuclein Pre-formed Fibril Propagation Model in Mice." Neurobiology of Aging. 85: 49–57 (2020). doi:10.1016/j.neurobiolaging.2019.09.012
Yang, X., J.K. Williams, R. Yan, M. M. Mouradian, and J. Baum. "Increased Dynamics of α-Synuclein Fibrils by β-Synuclein Leads to Reduced Seeding and Cytotoxicity." Scientific Reports. 9, 17579 (2019). doi:10.1038/s41598-019-54063-8
Williams, J.K., X. Yang, and J. Baum. "Interactions between the Intrinsically Disordered Proteins β-Synuclein and α-Synuclein." Proteomics. 1800109 (2018). doi:10.1002/pmic.201800109
Williams, J.K., X. Yang, T.B. Atieh, M.P. Olson, S.D. Khare, and J. Baum. "Multi-Pronged Interactions Underlie Inhibition of α-Synuclein Aggregation by β-Synuclein." J. Mol. Biol. 430: 2360-2371 (2018). doi:10.1016/j.jmb.2018.05.024
Moriarty, G.M., M.P. Olson, T.B. Atieh, M.K. Janowska, S.D. Khare, and J. Baum. “A pH-Dependent Switch Promotes β-Synuclein Fibril Formation via Glutamate Residues.” J. Biol. Chem. 292:16368–16379 (2017). doi:10.1074/jbc.M117.780528
Bennett, N.K., R. Chmielowski, D.S. Abdelhamid, J.J. Faig, N. Francis, J. Baum, Z.P. Pang, K.E. Uhrich, and P.V. Moghe. “Polymer Brain-Nanotherapeutics for Multipronged Inhibition of Microglial α-Synuclein Aggregation, Activation, and Neurotoxicity.” Biomaterials. 111:179–189 (2016). doi:10.1016/j.biomaterials.2016.10.001
Janowska, M.K. and J. Baum. “Intermolecular Paramagnetic Relaxation Enhancement (PRE) Studies of Transient Complexes in Intrinsically Disordered Proteins.” D. Eliezer (Ed.), Protein Amyloid Aggregation: Methods and Protocols, Methods in Molecular Biology, 1345:45–53 (2016). doi:10.1007/978-1-4939-2978-8_3
Janowska, M.K., K.-P. Wu, and J. Baum. “Unveiling Transient Protein-Protein Interactions that Modulate Inhibition of alpha-Synuclein Aggregation by beta-Synuclein, a Pre-Synaptic Protein that co-Localizes with alpha-Synuclein.” Sci. Rep. 5:15164 (2015). doi:10.1038/srep15164
Janowska, M.K. and J. Baum. “The Loss of Inhibitory C-Terminal Conformations in Disease Associated P123H β-synuclein.” Protein Science. 25:286–294 (2015). doi:10.1002/pro.2798
Moriarty, G.M., C.A.S.A. Minetti, D.P. Remeta, and J. Baum. “A Revised Picture of the Cu(II)−α-Synuclein Complex: The Role of N-Terminal Acetylation.” Biochemistry. 53:2815–2817 (2014). doi:10.1021/bi5003025
Selected COVID-19 Publications:
Williams J.K., B. Wang, A. Sam, C.L. Hoop, D.A. Case and J. Baum. "Molecular Dynamics Analysis of a Flexible Loop at the Binding Interface of the SARS-CoV-2 Spike Protein Receptor-Binding Domain." Proteins: Structure, Function, and Bioinformatics (2021). doi:10.1002/prot.26208