Research Projects

Knapp, Spencer

Project Description

Organic synthesis:

• Total synthesis of natural products
• New synthetic methods
• New drug delivery systems
• New anti-malarials
• Enzyme inhibitors, models, and mechanism

Qualifications

GPA: 3.5, chemistry major preferred

Course Experience:

• Organic chemistry – 1 year
• Organic lab – 1 or 2 semesters

Current Undergraduate Researchers

• Jonathan Tsui
• Aneesh Pirlamarla

Recent Publications with Undergraduate Co-authors (in bold)

Spencer Knapp, Chunhua Yang, and Thomas Haimowitz. “Addition of Trialkylaluminium Reagents to Glyconolactones. Synthesis of 1-C-Methyl GlcNAc Oxazoline and Thiazoline” Tetrahedron Lett. 2002, 43, 7101.

Spencer Knapp, Silvia Gonzales, David S. Myers, Lisa L. Eckman, and Carole A. Bewley. “A Shortcut to Mycothiol Analogues” Org. Lett. 2002, 4, 4337.

Thomas J. Emge, Matthew J. Clements, David S. Myers, and Spencer Knapp. “(5-Bromopyrrol-3-yl) cyclohexylmethanone” Acta Cryst, 2003, E59, 1.

Spencer Knapp, Benjamin Amorelli, Etzer Darout, Christian C. Ventocilla, Lawrence M. Goldman, Richard A. Huhn, and Ellen C. Minnihan. “A Family of Mycothiol Analogues” J. Carbohydr. Chem. 2005, 24, 103.

Spencer Knapp, Richard C. Huhn, and Benjamin Amorelli. “Thionation: GlcNAc-Thiazoline Triacetate {(3aR,5R,6S,7R,7aR)-5-Acetoxymethyl-6,7-diacetoxy-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2- d]thiazole}” Organic Syntheses 2007, 84, 68.

Spencer Knapp, Mohannad Abdo, Richard C. Huhn, Thomas J. Emge, Eun Ju Kim, and John A. Hanover. “Tautomeric Modifications of GlcNAc-Thiazoline” Org. Lett. 2007, 9, 2321.

Spencer Knapp, David Fash, Mohannad Abdo, Thomas J. Emge, and Paul R. Rablen. “GlcNAc-Thiazoline Conformations” Bioorg. Med. Chem. 2009, 17, 1831.