Effective Modulation of CNS Inhibitory Microenvironment using Bioinspired Hybrid‐Nanoscaffold‐Based Therapeutic Interventions
Prof. Ki-Bum Lee’s group at the Chemistry and Chemical Biology Department in Rutgers has led the development of an advanced spatiotemporally controlled in vivo drug delivery system for effective modulation of neuroinflammation that may help the treatment of spinal cord injury and other neurological disorders.
FIGURE DESCRIPTION: Current biomaterials‐based treatment of central nervous system (CNS) injuries has been hampered by the resulting neuroinhibitory microenvironment. By targeting two critical neuroinhibitory factors in a single platform, a biomimetic 3D porous hybrid nanoscaffold is created by developing viscous interfacial self‐assembly. The nanoscaffold‐based therapeutic interventions achieve functional recovery through reducing neuroinflammation and fibrotic scarring, thereby paving a new road for the biomaterials‐based treatment of CNS injuries.