To this end, Prof. KiBum Lee and his team members have recently published a comprehensive review focusing on four critical areas [Figure 1]: i) the concept of organoid and the historical advances of organoid technologies; ii) the conventional methods for the generation of organoids are described in terms of two parameters; physical cues and biochemical cues; iii) the functions of extracellular matrices with diverse natural/artificial materials to customize physical cues; and iv) genetic engineering techniques to control biochemical cues and disease modeling using gene-engineered organoids.

Furthermore, the future trends in developing tunable organoids in response to exogenous and endogenous cues are also discussed as the outlook for next-generation developmental studies, disease modeling, and therapeutics. This review article will inspire interest from various disciplines and highlight an upcoming field wherein biomaterial-based organoid engineering technologies for revealing pathogenesis, disease modeling for drug discovery, and finally, regenerative medicine.

Publication: This work was recently published in Advanced Materials, 2021,
Yi, S. A.; Zhang, Y.; Rathnam, C.; Pongkulapa. T.; Lee, K.-B.†, "Bioengineering Approaches for the Advanced Organoid Research", Advanced Materials, 2021,


Group Members

Ki Bum Lee Ph 
             KiBum Lee, Ph.D.

Letao Yang Ph           
           Sang Ah Yi, Ph.D.

Yixiao Zhang Update         
           Yixiao Zhang, Ph.D.

Jin Ha Choi       
     Christopher Rathnam, Ph.D.

Letao Yang Ph 
        Thanapat Pongkulapa