To this end, Prof. KiBum Lee and his team members have recently published a comprehensive review focusing on four critical areas [Figure 1]: i) the concept of organoid and the historical advances of organoid technologies; ii) the conventional methods for the generation of organoids are described in terms of two parameters; physical cues and biochemical cues; iii) the functions of extracellular matrices with diverse natural/artificial materials to customize physical cues; and iv) genetic engineering techniques to control biochemical cues and disease modeling using gene-engineered organoids.
Furthermore, the future trends in developing tunable organoids in response to exogenous and endogenous cues are also discussed as the outlook for next-generation developmental studies, disease modeling, and therapeutics. This review article will inspire interest from various disciplines and highlight an upcoming field wherein biomaterial-based organoid engineering technologies for revealing pathogenesis, disease modeling for drug discovery, and finally, regenerative medicine.
Publication: This work was recently published in Advanced Materials, 2021, doi.org/10.1002/adma.202007949
Yi, S. A.; Zhang, Y.; Rathnam, C.; Pongkulapa. T.; Lee, K.-B.†, "Bioengineering Approaches for the Advanced Organoid Research", Advanced Materials, 2021, https://doi.org/10.1002/adma.202007949
KiBum Lee, Ph.D.
Sang Ah Yi, Ph.D.
Yixiao Zhang, Ph.D.
Christopher Rathnam, Ph.D.