In a recently published review by Prof. Ki-Bum Lee and his team at CCB (https://kblee.rutgers.edu/), an extensive analysis of the current state-of-art advances and a perspective on key challenges in the field of extracellular vesicles was provided. In the first part, they introduced the biological context of extracellular vesicles and their composition, function, tissue origin, and size heterogeneities. In this section, they aimed to familiarize readers from fields of material science, chemistry, and bioengineering with the development history and current challenges of extracellular vesicle-based applications. Another goal of this section is to present readers with a diverse array of important biological problems of synthetic and cell-derived vesicles that can potentially inspire novel synthesis, engineering, and applications of magnetic nanomaterials. Next, they briefly overviewed current approaches to engineer magnetic nanomaterials, including doping, hybridization, functionalization, and synthesis of magnetic nanomaterial for biomedical applications. By learning from the numerous exceptional examples of magnetic-facilitated biomedical applications, the team hopes to inspire the precision design of magnetic nanomaterials for extracellular vesicle-based therapeutic and diagnostic development. Most importantly, in the third and fourth sections, they overviewed the current state-of-arts that integrate engineered magnetic nanomaterials into the extracellular vesicle-based diagnostic and therapeutic applications. In this way, the general design principles of magnetic nanomaterial facilitated theranostic applications of the extracellular vesicle was further elucidated by focusing on the most exciting articles as case studies.
In short, by providing cutting-edge knowledge about magnetic nanomaterials-facilitated isolation, detection, and delivery of extracellular vesicles, this newly published review article aim to engage the two crucial fields pertinent to material science and engineering into dialogue for better development of theranostic systems.
PUBLICATION: This work was recently published as a Cover article in Small.
Yang, L., Patel, K. D., Rathnam, C., Thangam, R., Hou, Y., Kang, H., & Lee, K. B. (2022). Harnessing the Therapeutic Potential of Extracellular Vesicles for Biomedical Applications Using Multifunctional Magnetic Nanomaterials. Small, 2104783.
KBLEE Group Team: Letao Yang, Ph.D., Brian M. Conley, Yannan Hou, https://kblee.rutgers.edu/
Professor KiBum Lee
Letao Yang, Ph.D.
Brian M. Conley